Harrison missed the first four games of the 2007 season to serve a suspension for violating the league's substance abuse policy. Harrison said he used "a banned substance" to accelerate the healing process from football-related injuries and never to gain a competitive edge. He returned to the team in a Week 5 win over the Cleveland Browns, and became the first player in NFL history to record both 30 interceptions and 30 sacks for his career later in the season.