Sept. 30, 2001: Patriots 44, Colts 13
Tom Brady's first NFL start was against the Colts, and while the defense played a central role in the victory (four turnovers, two interceptions returned for touchdowns), Brady didn't make any major mistakes. He completed 13 of 23 passes for 168 yards.
The week before, starter Drew Bledsoe was knocked out of a game vs. the Jets by hit that changed the course of Patriots history. Bledsoe never regained his full-time starting job because Brady did such a good job filling in for him. Peyton Manning finished with only 196 yards passing, going 20-for-34 with three picks to go against one TD pass.