Joffrey Lupul had a goal and two assists, Mikhail Grabovski and Colton Orr also scored, and James Reimer made 27 saves for Toronto, which led 5-1 midway through the third period.

Daniel Alfredsson scored twice for the Senators, coming off a 5-3 loss in Detroit on Friday night. Colin Greening, Jason Spezza and Stephane Da Costa, with his first in NHL goal, also scored, and Erik Karlsson had three assists.

Alex Auld took the loss in relief for Ottawa after allowing two goals in the third period. Craig Anderson started and gave up four goals on 20 shots through two periods.

Alfredsson made it a 5-2 at 11:04 of the third with a short-handed breakaway goal after taking a clearing attempt coming out of the penalty box.

The Senators then struck for a pair of power-play goals. Spezza scored with 4:24 left and Alfredsson got his second of the game on a deflection 8 seconds later.

Kessel replied for the Leafs with his third of the game with 2:19 left, snapping a shot over Auld's glove hand on a 2-on-1 rush.

But Ottawa struck back when Da Costa took a feed from Karlsson and scored with 1:54 to go.

Notes: Orr took Jay Rosehill's spot in the lineup for Toronto. ... Ottawa plays back-to-back games 16 times this season. ... The Maple Leafs started the season tied for the second youngest roster (26.3) in the league behind the Nashville Predators. ... The Leafs have a week off until they face Calgary at home next Saturday night. ... The Senators return to Ottawa for their home opener Tuesday night against Minnesota.