The top-ranked Williams, 28, has won three titles at Flushing Meadows, part of her 13 Grand Slam singles championships. Last year, she lost in the semifinals after a tirade at a line judge over a foot-fault call, an outburst that drew a record fine.

“It is with much frustration and deep sadness that I am having to pull out of the US Open,’’ Williams said in a statement released by her publicist.

“My doctors have advised against my playing so that my foot can heal.’’

She called missing the tournament, which begins Aug. 30, “one of the most devastating moments of my career.’’

Williams reportedly was hurt by a broken glass at a restaurant while she was in Munich — shortly after winning her fourth Wimbledon singles title July 3, and before playing in an exhibition against Kim Clijsters that drew a tennis-record crowd of 35,681 in Brussels July 8.

Williams had surgery in Los Angeles July 15. She already had pulled out of three hard-court tournaments she had entered in preparation for the US Open and also skipped playing World TeamTennis.

In last year’s Open, Williams lashed out at a lineswoman during her semifinal against Clijsters, the eventual champion. It was a profanity-laced, finger-pointing, racket-brandishing display. About 2 1/2 months later, Williams was fined $82,500 by the Grand Slam administrator.