CHICAGO -- Holiday revelers beware: Seasonal indulgences like eggnog and fruitcake might give you heartburn, but the acid-fighting medicine you take for relief might lead to something worse, researchers say.
People on popular prescription heartburn drugs -- Prilosec, Prevacid, and Nexium -- seem more prone to getting a potentially dangerous diarrhea caused by the bug Clostridium difficile, new research shows. C-diff, as it's known, can cause severe diarrhea and crampy intestinal inflammation called colitis.
Dr. Sandra Dial and colleagues at McGill University in Montreal examined data on more than 18,000 patients in the United Kingdom from 1994 to 2004. During that time, 1,672 cases of C-diff were diagnosed, and the numbers increased from less than 1 per 100,000 in 1994 to 22 per 100,000 last year.
Patients with prescriptions for powerful acid-fighters called proton pump inhibitors, which include Prilosec and Prevacid, were almost three times more likely to be diagnosed with the bug than those not taking the drugs. Those on less potent prescription drugs called H2 receptor antagonists, which include Pepcid and Zantac, were two times more likely than nonusers to get C-diff infections.
The widely used and heavily promoted drugs reduce levels of gastric acid that can keep C-diff germs at bay.
Dr. L. Clifford McDonald, a researcher at the federal Centers for Disease Control and Prevention, said proton pump inhibitors recently were implicated in a C-diff outbreak at a hospital and nursing homes in Maine.
''It's not surprising in my mind that there could be some association" with acid-fighting drugs, said McDonald, who was not involved in Dial's study. If there is, ''I do think it would be very important because, boy, everyone and their brother seems to be on them."
Most study patients hadn't been recently hospitalized and were not taking antibiotics, which both can increase risks for C-difficile infections.
Also, most patients hadn't been diagnosed with ulcers or acid reflux, so it's possible many simply had heartburn, Dial said.
''Heartburn in and of itself isn't dangerous," and can often be treated with less potent drugs, Dial said.
Her study will appear in tomorrow's Journal of the American Medical Association.
A coauthor is a consultant for
AstraZeneca spokeswoman Cindy Callaghan said patient safety is the company's top priority and that the findings are not the final word.
''Further research is needed in this particular area to determine the validity of a potential link," she said.
C-diff bacteria historically have been found in patients on antibiotics or with underlying illnesses, especially those in hospitals or nursing homes, but infections increasingly have been reported in the community.
Doctors think the growing trend is due in part to overuse of antibiotics, but the new data suggest overuse of acid-fighting drugs may be another reason, said Dr. Michael Brown, a gastroenterologist at Rush University Medical Center in Chicago, who was not involved in the study.