Joe Perry is coming home tonight

The Aerosmith guitarist and co-founder will play a hometown show at the House of Blues for his new solo album, “Sweetzerland Manifesto.”

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Joe Perry

Credit: Ross Halfin
Joe Perry. –Ross Halfin

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You can hear it clearly in his voice: Joe Perry is homesick.

“I miss Boston so much,” the Aerosmith guitarist said, with a genuine yearning lilt.

Perry spoke last week from Los Angeles, where the longtime Duxbury resident also has a home, and where he launched his sixth solo album, “Sweetzerland Manifesto,” in January with a star-studded show at LA’s Roxy Theatre.

The night’s lineup included Slash (Guns N’ Roses), Dean and Robert DeLeo (Stone Temple Pilots), and fellow Bostonian Gary Cherone (Extreme), along with the album’s collaborators: Robin Zander (Cheap Trick), David Johansen (New York Dolls), Johnny Depp (actor and Perry’s Hollywood Vampires bandmate), Chris Robinson (Black Crowes), and British blues veteran Terry Reid.

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Though Perry did a signing session at Newbury Comics in January, the bicoastal Lawrence native said he was very excited to play this short tour that puts him at Boston’s House of Blues on Wednesday, April 18, and at New Hampshire’s Hampton Beach Casino on Thursday, April 19.

“It’s fun here,” Perry said of LA, “but I miss the East Coast. I’m definitely looking forward to playing Boston. There will be lots of friends there.”

Indeed, Aerosmith bandmate Brad Whitford and Cherone are confirmed for the three-date East Coast tour. Opening the Boston show is North Shore guitarist Charlie Ferren, who played in The Joe Perry Project, a band Perry formed after Aerosmith’s “split” at the end of its roaring ‘70s run.

The rest of Perry’s year is stacked, as well: After he wraps up the tour this weekend, the guitar legend will go straight into Aerosmith action, performing at the 2018 New Orleans Jazz and Heritage Festival at the end of April. A Hollywood Vampires tour will follows from May through June, and there’s a new Vampires album to finish.

“Alice came in the other day to lay down his vocals,” Perry said of frontman Alice Cooper.

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For now, Perry is enjoying his solo shows, which, compared to the arenas Aerosmith plays, are in smaller venues, giving fans a real treat.

“It sounds better in smaller places, and I want the music to sound great,” Perry said. “It sounds the way it’s supposed to sound.”

The blues rock-based “Sweetzerland Manifesto,” which was recorded in Depp’s home studio in LA, began as an instrumental record, but producer Jack Douglas, who helmed Aerosmith’s classic 1970s albums, lives nearby and dropped in and gave some advice.

“When he heard some of the music, he said, ‘Why don’t you get David Johansen to sing?’ I said, ‘Hell, yeah!’ Next thing, Jack said, ‘Terry Reid lives in Palm Springs…’” Perry said, pausing.

“You gotta know who he is?” Perry continued, speaking rhetorically of the English blues singer, who, despite success during the late ’60s and ’70s, isn’t necessarily a household name. He was one of the first. He is going to sit in on a couple of songs at the House of Blues. I love the way he sings. The joy and agony of his life — you can hear it in his music.”

While it may seem like all of this came together easily, Perry said that it isn’t always as simple as it sounds.

“Oh, there’s plenty of stress,” he said. “But I keep it as stress-free as possible. If we’re not having fun, then I don’t want to do it.”