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Watch: A fan holding a sign at the Tour de France interfered and caused a massive crash

Once one cyclist fell, many more followed like bowling pins.

The pack rides during the 1st stage of the 108th edition of the Tour de France. Anne-Christine Poujoulat/AFP via Getty Images

A fan holding a cardboard sign at the Tour de France impeded the progress of cyclists and caused a major crash during stage 1 of the race Saturday.

According to cyclingnews.com, the incident took place with 45km to go. Once one cyclist fell, many more followed like bowling pins.

The peloton quickly neutralized the stage to allow riders to receive medical treatment, cyclingnews.com reported. According to NBC Sports, Jasha Sütterlin was forced to withdraw as a result of the collision.

Many are describing it as one of the most significant crashes in the history of the event.

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There was then a second major crash later in the day as well.

The event runs through July 18.

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